3. Multi-component Fitting

gamma-TEMPy uses a genetic algorithm to assemble component models simultaneously in a map. The fitness function combines a mutual information score that quantifies the goodness of fit with a penalty score that helps to avoid clashes between components. A tutorial is available. The test data and the script (gamma_tempy.py) are in Examples.

For more information:

  • Pandurangan AP, Vasishtan D, Alber F, Topf M. (2015) γ-TEMPy: Simultaneous Fitting of Components in 3D-EM Maps of Their Assembly Using a Genetic Algorithm. Structure. 23(12), 2365–2376.